Research Subject

Deciphering the molecular and cellular basis of the induction and maintenance of hair follicle stem cells at single cell resolution

Hironobu Fujiwara

RIKEN Center for Developmental Biology
Laboratory for Tissue Microenvironment
Team Leader

RIKEN Center for Developmental Biology(CDB), 2-2-3 Minatojima-minamimachi, Chuou-ku, Kobe 650-0047

The hair follicle stem cell research has been mainly focused on established “adult” stem cells and revealed many important mechanisms of adult stem cell regulation, including the stem cell heterogeneity, stem cell quiescence and activation, and reciprocal regulations between stem cells and their niche. On the other hand, “the origin and induction mechanisms” of tissue stem cells in the developmental process is obscure. For example, it is elusive how the early hair follicle stem cells are induced from a seemingly uniform undifferentiated progenitor cells at the right time in the right place. We aim to understand this by integrating data from different single cell analysis.


3D immunofluorescent image of mouse hair follicle epidermis

Team Member